Article
Disequilibrium likelihoods for fine-scale mapping of a rare allele.
American journal of human genetics - 1 Nov 1998
Graham J, Thompson E A
Abstract excerpt
Genetic linkage studies based on pedigree data have limited resolution, because of the relatively small number of segregations. Disequilibrium mapping, which uses population associations to infer the location of a disease mutation, provides one possible strategy for narrowing the candidate region. The coalescent process provides a model for the ancestry of a sample of disease alleles, and recombination events...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.