Disequilibrium likelihoods for fine-scale mapping of a rare allele.

doi:10.1086/302102

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Article

Disequilibrium likelihoods for fine-scale mapping of a rare allele.

American journal of human genetics - 1 Nov 1998

Graham J, Thompson E A

Abstract excerpt

Genetic linkage studies based on pedigree data have limited resolution, because of the relatively small number of segregations. Disequilibrium mapping, which uses population associations to infer the location of a disease mutation, provides one possible strategy for narrowing the candidate region...

Topics

Algorithms
Alleles
Chromosome Mapping
Female
Genetic Diseases, Inborn
Humans
Likelihood Functions
Linkage Disequilibrium
Male
Models, Genetic
Models, Statistical
Pedigree
Recombination, Genetic
Reproducibility of Results

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