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Reversal of malignant phenotype in human osteosarcoma cells transduced with the alkaline phosphatase gene.

Bone - 1 Mar 2000

Manara M C, Baldini N, Serra M, Lollini P L, De Giovanni C, Vaccari M, Argnani A, Benini S, Maurici D, Picci P, Scotlandi K

Abstract excerpt

Alkaline phosphatases are a family of glycoproteins that are able to hydrolize various monophosphate esters at a high pH optimum. Liver/bone/kidney (L/B/K) alkaline phosphatase (ALP) is one of the four major isoenzymes that belong to this family. Apart from its role in normal bone mineralization, other functions of L/B/K ALP remain obscure, both in physiological and in neoplastic conditions, including the...

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Identifiers

PMID: 10709992
DOI: 10.1016/s8756-3282(99)00266-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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