Article
Apoptotic genes as potential markers of metastatic phenotype in human osteosarcoma cell lines.
International journal of oncology - 1 Jan 2008
Zucchini Cinzia, Rocchi Anna, Manara Maria Cristina, De Sanctis Paola, Capanni Cristina, Bianchini Michele, Carinci Paolo, Scotlandi Katia, Valvassori Luisa
Abstract excerpt
Metastasis is the most frequent cause of death among patients with osteosarcoma. We have previously demonstrated in independent experiments that the forced expression of L/B/K ALP and CD99 in U-2 OS osteosarcoma cell lines markedly reduces the metastatic ability of these cancer cells. This behavior makes these cell lines a useful model to assess the intersection of multiple and independent gene expression...
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