Article
Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage.
Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 2008
Berman Seth D, Calo Eliezer, Landman Allison S, Danielian Paul S, Miller Emily S, West Julie C, Fonhoue Borel Djouedjong, Caron Alicia, Bronson Roderick, Bouxsein Mary L, Mukherjee Siddhartha, Lees Jacqueline A
Abstract excerpt
Mutation of the RB-1 and p53 tumor suppressors is associated with the development of human osteosarcoma. With the goal of generating a mouse model of this disease, we used conditional and transgenic mouse strains to inactivate Rb and/or p53 specifically in osteoblast precursors. The resulting Rb;p53 double mutant (DKO) animals are viable but develop early onset osteosarcomas with complete penetrance. These tumors...
Topics
- Animals
- Antigens, Ly
- Biomarkers, Tumor
- Cell Differentiation
- Cell Lineage
- Cell Transformation, Neoplastic
- Disease Models, Animal
- Genotype
- Membrane Proteins