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Genetically transforming human osteoblasts to sarcoma: development of an osteosarcoma model

2 Mar 2017

Abstract excerpt

Osteosarcoma is the most common primary malignant bone tumor in children and young adults. Although histologically defined by the presence of malignant osteoid, the tumor possesses lineage multipotency suggesting it could be derived from a cell anywhere on the differentiation pathway between a mesenchymal stem cell (MSC) and a mature osteoblast. To determine if preosteoblasts (pOB) could be the cell of origin...

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PMID: 28435520
DOI: 10.18632/genesandcancer.133

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