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Article

Hypervariable region 1 sequence stability during hepatitis C virus replication in chimpanzees.

Journal of virology - 1 Apr 2000

Ray S C, Mao Q, Lanford R E, Bassett S, Laeyendecker O, Wang Y M, Thomas D L

Abstract excerpt

The putative envelope 2 (E2) gene of hepatitis C virus (HCV) contains a highly variable region referred to as hypervariable region 1 (HVR1). We hypothesized that this genetic variability is driven by immune selection pressure, rather than representing the accumulation of random mutations in a region with relatively little functional constraint. To test this hypothesis, we examined the E2 sequence of a human...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Polymorphism, Single-Stranded Conformational

Share to Sequence Homology, Amino Acid

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Source

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Identifiers

PMID: 10708420
DOI: 10.1128/jvi.74.7.3058-3066.2000
PMCID: PMC111804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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