Article
Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability.
Virology - 1 Oct 1992
Okamoto H, Kojima M, Okada S, Yoshizawa H, Iizuka H, Tanaka T, Muchmore E E, Peterson D A, Ito Y, Mishiro S
Abstract excerpt
Extensive variability in genomic sequence, especially at "hypervariable regions" within the NS1/E2 region of the long open reading frame, has been reported for RNA cloned from hepatitis C virus (HCV)-infected humans and chimpanzees. However, genetic changes of HCV occurring during the course of chronic infections in humans and animals have been evaluated only for partial sequences of the HCV genome. We compared...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Capsid
- Gene Frequency
- Genetic Variation
- Hepacivirus
- Hepatitis C
- Molecular Sequence Data
- Pan troglodytes
- Viral Core Proteins