Emergence of a distinct pattern of viral mutations in chimpanzees infected with a homogeneous inoculum of hepatitis C virus.

doi:10.1053/gast.2001.28669

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Article

Emergence of a distinct pattern of viral mutations in chimpanzees infected with a homogeneous inoculum of hepatitis C virus.

Gastroenterology - 1 Nov 2001

Thomson M, Nascimbeni M, Gonzales S, Murthy K K, Rehermann B, Liang T J

Abstract excerpt

BACKGROUND & AIMS: Prospective, long-term study of viral evolution and immunologic responses in chimpanzees infected with a homogeneous hepatitis C virus (HCV) population is crucial in understanding the pathogenesis of HCV-host interactions. METHODS: A molecular clone was constructed of HCV genotype 1b and RNA transcribed from this clone inoculated intrahepatically into chimpanzee X0142. Serum was taken from...

Topics

Alanine Transaminase
Animals
Base Sequence
DNA, Complementary
DNA, Viral
Genotype
Hepacivirus
Molecular Sequence Data
Mutation
Pan troglodytes
RNA, Viral
Viral Nonstructural Proteins

Source

Open in PubMed

Identifiers

PMID: 11677216
DOI: 10.1053/gast.2001.28669

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