Article
Longitudinal analysis of hepatitis C virus infection and genetic drift of the hypervariable region.
The Journal of infectious diseases - 1 Jun 1994
van Doorn L J, Quint W, Tsiquaye K, Voermans J, Paelinck D, Kos T, Maertens G, Schellekens H, Murray K
Abstract excerpt
Hepatitis C virus (HCV) infections in a cohort of chimpanzees were studied retrospectively. All animals had been inoculated intravenously with materials derived from a single-source chimpanzee plasma implicated in non-A, non-B hepatitis, prepared by extensive ultracentrifugation. Anti-HCV and HCV RNA were monitored by the confirmatory line immunoassay and by an RNA-capture polymerase chain reaction method,...
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