Article
Human Immunodeficiency Virus Seroconversion and Evolution of the Hepatitis C Virus Quasispecies
1 Apr 2001
Abstract excerpt
When chronic hepatitis C virus (HCV) infections are complicated by acquisition of human immunodeficiency virus (HIV), liver disease appears to accelerate and serum levels of HCV RNA may rise. We hypothesized that HIV might affect the HCV quasispecies by decreasing both complexity (if HIV-induced immunosuppression lessens pressure for selecting HCV substitutions) and the ratio of nonsynonymous (d(N)) to synonymous...
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