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Article

Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas.

Virchows Archiv : an international journal of pathology - 1 May 2003

Wang Jaw-Yuan, Huang Tsung-Jen, Chen Fang-Ming, Hsieh Ming-Chia, Lin Shiu-Ru, Hou Ming-Feng, Hsieh Jan-Sing

Abstract excerpt

A novel tumor suppressor gene, PTEN/MMAC1, located on chromosome band 10q23.3, encodes a 403-amino acid, dual-specificity protein phosphatase. The defects in this gene are responsible for the development of some advanced cancers. Inactivating alterations, including mutations and deletions, in the PTEN/MMAC1 gene have been identified in several types of human cancers and cancer cell lines. To clarify the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12695913
DOI: 10.1007/s00428-003-0803-5

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas.PMID 12695913Read ↗

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Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity.Semantic proximity Read ↗

Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles.Semantic proximity Read ↗

PTEN/MMAC1 mutations in endometrial cancers.Semantic proximity Read ↗

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.Semantic proximity Read ↗

Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis.Semantic proximity Read ↗

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Mutation analysis of the PTEN/MMAC1 gene in lung cancer.Semantic proximity Read ↗

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