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Article

Mutation analysis of PTEN/MMAC 1 in sporadic thyroid tumors.

The Kaohsiung journal of medical sciences - 1 Jan 2000

Hsieh M C, Lin S F, Shin S J, Liu T C, Chang J G, Lee J P

Abstract excerpt

Recently, a putative tumor suppressor gene, PTEN/MMAC1, has been identified at chromosome 10q23.3. This gene encodes a 403 amino acid dual specificity phosphatase containing a region of homology to tensin and auxillin. Somatic mutations of the PTEN/MMAC1 gene have been found in a number of cancer...

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Source

Identifiers

PMID: 10741010

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10741010-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Mutation analysis of PTEN/MMAC 1 in sporadic thyroid tumors.PMID 10741010Read ↗

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Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancer.Semantic proximity Read ↗

Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas.Semantic proximity Read ↗

Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles.Semantic proximity Read ↗

Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation.Semantic proximity Read ↗

Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas.Semantic proximity Read ↗

A novel mutation of the PTEN gene in a Japanese patient with Cowden syndrome and bilateral breast cancer.Semantic proximity Read ↗

Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis.Semantic proximity Read ↗

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