Genetic analysis of mitomycin C-hypersensitive Chinese hamster cell mutants.

doi:10.1093/mutage/9.5.477

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Article

Genetic analysis of mitomycin C-hypersensitive Chinese hamster cell mutants.

Mutagenesis - 1 Sept 1994

Jones N J

Abstract excerpt

The genetic diversity of Chinese hamster cell mutants exhibiting hypersensitivity to the bifunctional alkylating agent mitomycin C has been examined. The eight mutants irs3, VH4, UV1, MC5, MMC1, MMC3, MMC4 and MMS2, are between 4- and 30-fold more sensitive to mitomycin C than their respective wi...

Topics

Animals
Cell Line
Cricetinae
DNA Damage
Drug Resistance
Fanconi Anemia
Genetic Complementation Test
Genetic Variation
Humans
Hybridization, Genetic
Mitomycin
Mutation
Phenotype

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