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Article

Differential Toxicity of DNA Adducts of Mitomycin C

1 Jan 2010

Abstract excerpt

The clinically used antitumor agent mitomycin C (MC) alkylates DNA upon reductive activation, forming six covalent DNA adducts in this process. This paper focuses on differential biological effects of individual adducts in various mammalian cell cultures, observed in the authors' laboratories. Evidence is reviewed that various adducts are capable of inducing different cell death pathways in cancer cells. This...

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PMID: 20798760
DOI: 10.4061/2010/698960

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