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Article

Experimental and theoretical studies of the effects of deoxyribose substitutions on the stability of the UUCG tetraloop.

Journal of molecular biology - 17 Mar 2000

Williams D J, Hall K B

Abstract excerpt

Experimental and theoretical thermodynamic studies of the consequences of 2'-hydroxyl substitution in the RNA UUCG tetraloop show distinct position dependence consistent with the diverse structural contexts of the four-loop ribose hydroxyls in this motif. The results suggest that even for simple substitutions, such as the replacement of the ribose hydroxyl (2'-OH) with hydrogen (2'-H), the free energy change...

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Identifiers

PMID: 10704320
DOI: 10.1006/jmbi.2000.3547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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