Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bases defining an ammonium and magnesium ion-dependent tertiary structure within the large subunit ribosomal RNA.

Journal of molecular biology - 16 Dec 1994

Lu M, Draper D E

Abstract excerpt

A 58 nucleotide RNA derived from a highly conserved domain of the large subunit ribosomal RNA (Escherichia coli 1051 to 1108) has a set of tertiary interactions that is stabilized by NH4+ and Mg2+ in preference to other ions. We have mapped the nucleotides contributing to this structure by examining the thermal denaturation of 25 sequence variants. Where necessary compensatory mutations were made to preserve the...

Topics

Base Composition
Base Sequence
Cations, Monovalent
Escherichia coli
Magnesium
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Nucleic Acid Denaturation
Quaternary Ammonium Compounds
RNA, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Ribosomal

Temperature

Thermodynamics

Source

Identifiers

PMID: 7527467
DOI: 10.1006/jmbi.1994.1753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7527467-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bases defining an ammonium and magnesium ion-dependent tertiary structure within the large subunit ribosomal RNA.PMID 7527467Read ↗

Structure of the human 80S ribosome at 1.9 Å resolution – the molecular role of chemical modifications and ions in RNASemantic proximity Read ↗

Detection of a key tertiary interaction in the highly conserved GTPase center of large subunit ribosomal RNA.Semantic proximity Read ↗

Stabilization of RNA tertiary structure by monovalent cations.Semantic proximity Read ↗

Structure and function of the conserved 690 hairpin in Escherichia coli 16 S ribosomal RNA: analysis of the stem nucleotides.Semantic proximity Read ↗

The A2453-C2499 wobble base pair in Escherichia coli 23S ribosomal RNA is responsible for pH sensitivity of the peptidyltransferase active site conformation.Semantic proximity Read ↗

An RNA structural determinant for tRNA recognition.Semantic proximity Read ↗

Experimental and theoretical studies of the effects of deoxyribose substitutions on the stability of the UUCG tetraloop.Semantic proximity Read ↗

Purine bases at position 37 of tRNA stabilize codon-anticodon interaction in the ribosomal A site by stacking and Mg2+-dependent interactions.Semantic proximity Read ↗

Potential new antibiotic sites in the ribosome revealed by deleterious mutations in RNA of the large ribosomal subunit.Semantic proximity Read ↗

Optimization of a ribosomal structural domain by natural selection.Semantic proximity Read ↗

30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtCSemantic proximity Read ↗

Specific length and structure rather than high thermodynamic stability enable regulatory mRNA stem-loops to pause translationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.