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Article

Thermodynamic Stability of DNA Duplexes Comprising the Simplest T → dU Substitutions.

Biochemistry - 2 Oct 2018

Carr Carolyn E, Khutsishvili Irine, Gold Barry, Marky Luis A

Abstract excerpt

Members of the uracil-DNA glycosylase (UDG) enzyme family recognize and bind uracil, sequestering it within the binding site pocket and catalyzing the cleavage of the base from the deoxyribose, leaving an abasic site. The recognition and binding are passive and rely on innate dynamic motions of DNA wherein base pairs undergo thermally induced breakage and conformational fluctuations. Once the uracil breaks from...

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Identifiers

PMID: 30185020
DOI: 10.1021/acs.biochem.8b00676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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