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Article

Effects of base substitutions in an RNA hairpin from molecular dynamics and free energy simulations.

Biophysical journal - 1 Dec 2003

Sarzynska Joanna, Nilsson Lennart, Kulinski Tadeusz

Abstract excerpt

Contributions of individual interactions in the GGCGCAAGCC hairpin containing a GCAA tetraloop were studied by computer simulations using base substitutions. The G in the first tetraloop position was replaced by inosine (I) or adenosine (A), and the G in the C-G basepair closing the tetraloop was replaced by I. These substitutions eliminate particular hydrogen bonds proposed in the nuclear magnetic resonance...

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Identifiers

PMID: 14645041
DOI: 10.1016/S0006-3495(03)74766-3
PMCID: PMC1303653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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