Article
Transcriptional control for initiation of chromosomal replication in Escherichia coli: fluctuation of the level of origin transcription ensures timely initiation.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Sept 2003
Su'etsugu Masayuki, Emoto Akiko, Fujimitsu Kazuyuki, Keyamura Kenji, Katayama Tsutomu
Abstract excerpt
BACKGROUND: During the cell cycle, the initiation of chromosomal replication is strictly controlled. In Escherichia coli, the initiator DnaA and the replication origin oriC are major targets for this regulation. Here, we assessed the role of transcription of the mioC gene, which reads through the adjacent oriC region. This mioC-oriC transcription is regulated in coordination with the replication cycle so that it...
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