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Article

The defects in effector generation associated with aging can be reversed by addition of IL-2 but not other related gamma(c)-receptor binding cytokines.

Vaccine - 25 Feb 2000

Haynes L, Eaton S M, Swain S L

Abstract excerpt

Aged naive CD4 T cells produce low levels of IL-2, leading to inefficient generation of effectors. The cells expand poorly, giving rise to few effectors with less activated phenotypes and reduced ability to produce cytokines. The aged cells also respond less vigorously in vivo. Addition of exogenous IL-2 or other gamma(c) receptor-signaling cytokines, restores expansion. However, only effectors generated in the...

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PMID: 10689143
DOI: 10.1016/s0264-410x(99)00501-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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