Naive CD4(+) lymphocytes convert to anergic or memory-like cells in T cell-deprived recipients.

Abstract excerpt

Recent demonstrations that naive T cells proliferate after transfer to lymphopenic hosts have led to the theory that active homeostatic mechanisms fill the peripheral pool of naive T cells. To extend these data, we injected naive CD4(+) T cells from AND TCR transgenic mice (H-2(b/b) or H-2(k/k)) into CD3 epsilon-deficient mice, and studied the absolute number, phenotype and functional capacities of the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adoptive Transfer
• Share to CD3 Complex
• Share to CD4-Positive T-Lymphocytes