Article
The in vitro senescence of human T lymphocytes: failure to divide is not associated with a loss of cytolytic activity or memory T cell phenotype.
Mechanisms of ageing and development - 1 Feb 1993
Perillo N L, Naeim F, Walford R L, Effros R B
Abstract excerpt
Normal human T lymphocytes, activated in vitro and cultured in the continuous presence of the growth factor interleukin 2 (IL2), have a limited proliferative potential. Senescent T cell cultures will not proliferate, even if restimulated by the original allogeneic stimulator cells. However, we have now observed that such restimulation induces an increase in the percentage of cells expressing the 55 kDa chain of...
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