Article
Thymic output in aged mice.
Proceedings of the National Academy of Sciences of the United States of America - 30 May 2006
Hale J Scott, Boursalian Tamar E, Turk Gail L, Fink Pamela J
Abstract excerpt
Using GFP to mark recent thymic emigrants (RTEs) in mice carrying a GFP transgene driven by the recombination-activating gene 2 promoter, we demonstrate that RTEs are readily detectable even in 2-year-old mice, despite the fact that the proportion of the peripheral T cell pool comprised of RTEs declines with age. Although the number of RTEs decreases after reaching a peak at 6 weeks of age, thymic output as a...
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