Age-related changes in CD8 T cell homeostasis and immunity to infection.

doi:10.1016/j.smim.2012.04.009

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Article

Age-related changes in CD8 T cell homeostasis and immunity to infection.

Seminars in immunology - 1 Oct 2012

Nikolich-Žugich Janko, Li Gang, Uhrlaub Jennifer L, Renkema Kristin R, Smithey Megan J

Abstract excerpt

Studies of CD8 T cell responses to vaccination or infection with various pathogens in both animal models and human subjects have revealed a markedly consistent array of age-related defects. In general, recent work shows that aged CD8 T cell responses are decreased in magnitude, and show poor differentiation into effector cells, with a reduced arsenal of effector functions. Here we review potential mechanisms...

Topics

Aging
Animals
CD8-Positive T-Lymphocytes
Homeostasis
Humans
Immunity, Innate
Infections
Phenotype

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Identifiers

PMID: 22554418
DOI: 10.1016/j.smim.2012.04.009
PMCID: PMC3480557

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