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Article

Cell-intrinsic defects in the proliferative response of antiviral memory CD8 T cells in aged mice upon secondary infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2010

Decman Vilma, Laidlaw Brian J, Dimenna Lauren J, Abdulla Sarah, Mozdzanowska Krystyna, Erikson Jan, Ertl Hildegund C J, Wherry E John

Abstract excerpt

Although previous studies have demonstrated delayed viral clearance and blunted effector T cell responses in aged mice during infection, memory CD8 T cells and especially secondary responses have received less attention. In this study, we show that modest differences in the number of memory CD8 T cells formed in aged versus young animals were associated with altered memory CD8 T cell differentiation. Aged immune...

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Identifiers

PMID: 20368274
DOI: 10.4049/jimmunol.0902063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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