Article
Memory-type CD8+ T cells protect IL-2 receptor alpha-deficient mice from systemic infection with herpes simplex virus type 2.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2000
Tsunobuchi H, Nishimura H, Goshima F, Daikoku T, Nishiyama Y, Yoshikai Y
Abstract excerpt
IL-2Ralpha-deficient (IL-2Ralpha(-/-)) mice exhibit an impaired activation-induced cell death for T cells and develop abnormal T cell activation with age. In our study, we found that IL-2Ralpha(-/-) mice at the age of 5 wk contained an increased number of CD44(+)CD69(-)CD8(+) T cells in lymph nodes, which expressed a high intensity of IL-2Rbeta and vigorously proliferated in response to a high dose of IL-15 or...
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