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Article

Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion.

Science (New York, N.Y.) - 25 Feb 2000

Odenbreit S, Püls J, Sedlmaier B, Gerland E, Fischer W, Haas R

Abstract excerpt

The Gram-negative bacterium Helicobacter pylori is a causative agent of gastritis and peptic ulcer disease in humans. Strains producing the CagA antigen (cagA(+)) induce strong gastric inflammation and are strongly associated with gastric adenocarcinoma and MALT lymphoma. We show here that such strains translocate the bacterial protein CagA into gastric epithelial cells by a type IV secretion system, encoded by...

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Identifiers

PMID: 10688800
DOI: 10.1126/science.287.5457.1497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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