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Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus

1 Apr 2000

Abstract excerpt

Helicobacter pylori is one of the most common bacterial pathogens, infecting about 50% of the world population. The presence of a pathogenicity island (PAI) in H. pylori has been associated with gastric disease. We present evidence that the H. pylori protein encoded by the cytotoxin-associated gene A (cagA) is translocated and phosphorylated in infected epithelial cells. Two-dimensional gel electrophoresis (2-DE)...

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Identifiers

PMID: 11207572
DOI: 10.1046/j.1462-5822.2000.00043.x

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