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Article

Identification of mechanisms underlying transporter associated with antigen processing deficiency in metastatic murine carcinomas.

Cancer research - 15 Aug 2005

Setiadi A Francesca, David Muriel D, Chen Susan S, Hiscott John, Jefferies Wilfred A

Abstract excerpt

Expression of transporter associated with antigen processing (TAP) is often lost in metastatic carcinomas, resulting in defective antigen processing and presentation and escape of the cancer cells from immune surveillance. In this study, the nature of TAP deficiencies in tumors was investigated. By chromatin immunoprecipitation assay, we showed that the recruitment of RNA polymerase II to the TAP-1 gene was...

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Source

Identifiers

PMID: 16103103
DOI: 10.1158/0008-5472.CAN-03-3734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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