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Article

High frequency of functionally active Melan-a-specific T cells in a patient with progressive immunoproteasome-deficient melanoma.

Cancer research - 1 Sept 2004

Meidenbauer Norbert, Zippelius Alfred, Pittet Mikaël J, Laumer Monika, Vogl Sandra, Heymann Jana, Rehli Michael, Seliger Barbara, Schwarz Stephan, Le Gal Frederique-Anne, Dietrich Pierre Y, Andreesen Reinhard, Romero Pedro, Mackensen Andreas

Abstract excerpt

Tumor-reactive T cells play an important role in cancer immunosurveillance. Applying the multimer technology, we report here an unexpected high frequency of Melan-A-specific CTLs in a melanoma patient with progressive lymph node metastases, consisting of 18 and 12.8% of total peripheral blood and tumor-infiltrating CD8+ T cells, respectively. Melan-A-specific CTLs revealed a high cytolytic activity against...

Topics

Antigens, Neoplasm
Cysteine Endopeptidases
HLA-A2 Antigen
Humans
Lymph Nodes
MART-1 Antigen
Male
Melanoma
Middle Aged
Multienzyme Complexes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Proteins

Proteasome Endopeptidase Complex

T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 15342421
DOI: 10.1158/0008-5472.CAN-04-1341

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