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Article

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.

Molecular and cellular biology - 1 Aug 2003

Ding Qi, Reddy Yeturu V R, Wang Wei, Woods Timothy, Douglas Pauline, Ramsden Dale A, Lees-Miller Susan P, Meek Katheryn

Abstract excerpt

The DNA-dependent protein kinase (DNA-PK) plays an essential role in nonhomologous DNA end joining (NHEJ) by initially recognizing and binding to DNA breaks. We have shown that in vitro, purified DNA-PK undergoes autophosphorylation, resulting in loss of activity and disassembly of the kinase com...

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Identifiers

PMID: 12897153
DOI: 10.1128/MCB.23.16.5836-5848.2003
PMCID: PMC166339

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12897153-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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