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Article

Interaction of the yeast DExH-box RNA helicase prp22p with the 3' splice site during the second step of nuclear pre-mRNA splicing.

Nucleic acids research - 15 Mar 2000

McPheeters D S, Schwer B, Muhlenkamp P

Abstract excerpt

Using site-specific incorporation of the photo-chemical cross-linking reagent 4-thiouridine, we demonstrate the previously unknown association of two proteins with yeast 3' splice sites. One of these is an unidentified approximately 122 kDa protein that cross-links to 3' splice sites during formation of the pre--spliceosome. The other factor is the DExH-box RNA helicase, Prp22p. With substrates functional in the...

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Identifiers

PMID: 10684925
DOI: 10.1093/nar/28.6.1313
PMCID: PMC111051

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