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Article

How Slu7 and Prp18 cooperate in the second step of yeast pre-mRNA splicing.

RNA (New York, N.Y.) - 1 Aug 2002

James Shelly-Ann, Turner William, Schwer Beate

Abstract excerpt

Slu7 and Prp18 act in concert during the second step of yeast pre-mRNA splicing. Here we show that the 382-amino-acid Slu7 protein contains two functionally important domains: a zinc knuckle (122CRNCGEAGHKEKDC135) and a Prp18-interaction domain (215EIELMKLELY224). Alanine cluster mutations of 215EIE217 and 221LELY224 abrogated Slu7 binding to Prp18 in a two-hybrid assay and in vitro, and elicited...

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Source

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Identifiers

PMID: 12212850
DOI: 10.1017/s1355838202022033
PMCID: PMC1370317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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