Article
Mutations in the reduced-folate carrier affect protein localization and stability.
The Biochemical journal - 1 Mar 2000
Sadlish H, Murray R C, Williams F M, Flintoff W F
Abstract excerpt
The reduced-folate-carrier (rfc) gene has been shown to be functionally important for reduced-folate transport in mammalian cells. In the present paper we describe the identification of alterations in both alleles of the rfc gene in a mutant Chinese-hamster ovary cell line deficient in methotrexate transport. One allele of the rfc gene contains a point mutation resulting in a Gly(345)-->Arg substitution in the...
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