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Article

Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake.

The Journal of biological chemistry - 17 Feb 1995

Williams F M, Flintoff W F

Abstract excerpt

A clone has been isolated from a human lymphoblastic cDNA expression library that complements a mutant Chinese hamster cell defective in the uptake of the folate analogue methotrexate. When transfected with this clone the mutant cells regain the ability to transport the drug and, as a consequence, become sensitive to its cytotoxic action. The clone is 2863 base pairs long and has an open reading frame of 1770...

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PMID: 7852378
DOI: 10.1074/jbc.270.7.2987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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