Article
Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2001
Whetstine J R, Gifford A J, Witt T, Liu X Y, Flatley R M, Norris M, Haber M, Taub J W, Ravindranath Y, Matherly L H
Abstract excerpt
The presence of sequence variants in the human reduced folate carrier (hRFC) was assessed in leukemia blasts from children with acute lymphoblastic leukemia (ALL) and in normal peripheral blood specimens. A CATG frame shift insertion at position 191 was detected in 10-60% of hRFC transcripts from 10 of 16 ALL specimens, by RFLP analysis and direct sequencing of hRFC cDNAs. In genomic DNAs prepared from 105...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.