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Article

Methotrexate Transport and Resistance

1 Jan 1998

Abstract excerpt

Methotrexate (MTX), the antifolate drug widely used as both an anticancer chemotherapeutic drug and as an immunosuppressive agent, mimics natural folates to inhibit critical cellular biosynthetic pathways. One of the most important determinants of cellular sensitivity to MTX is the degree to which this drug is internalized by cancer cells, and one of the major pathways of folate uptake results from the activity...

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PMID: 9713954
DOI: 10.3109/10428199809057535

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