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Article

Functional analysis of altered reduced folate carrier sequence changes identified in osteosarcomas.

Biochimica et biophysica acta - 14 Oct 2004

Flintoff Wayne F, Sadlish Heather, Gorlick Richard, Yang Rui, Williams Frederick M R

Abstract excerpt

Osteosarcomas are common primary malignant bone tumors that do not respond to conventional low-dose treatments of methotrexate (Mtx), suggesting an intrinsic resistance to this drug. Previous work has shown that cDNAs generated from osteosarcoma mRNA from a fraction of patients contain sequence changes in the reduced folate carrier (RFC), the membrane protein transporter for Mtx. In this study, the functionality...

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Identifiers

PMID: 15469899
DOI: 10.1016/j.bbadis.2004.05.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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