Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line.

doi:10.1074/jbc.270.39.22974

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Article

Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line.

The Journal of biological chemistry - 29 Sept 1995

Brigle K E, Spinella M J, Sierra E E, Goldman I D

Abstract excerpt

This laboratory previously described an L1210 leukemia cell line (MTXrA) selected for resistance to methotrexate by virtue of impaired transport due to a functional defect in the translocation process. We now report on the sequence analysis of cDNAs encoding the reduced folate carrier from this l...

Topics

Alleles
Amino Acid Sequence
Animals
Antimetabolites, Antineoplastic
Base Sequence
CHO Cells
Carrier Proteins
Cloning, Molecular
Codon
Conserved Sequence
Cricetinae
DNA Primers
Leukemia L1210
Membrane Proteins
Membrane Transport Proteins
Methotrexate
Mice
Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 7559435
DOI: 10.1074/jbc.270.39.22974

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7559435-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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