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Article

Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line.

The Journal of biological chemistry - 29 Sept 1995

Brigle K E, Spinella M J, Sierra E E, Goldman I D

Abstract excerpt

This laboratory previously described an L1210 leukemia cell line (MTXrA) selected for resistance to methotrexate by virtue of impaired transport due to a functional defect in the translocation process. We now report on the sequence analysis of cDNAs encoding the reduced folate carrier from this line and identify a single mutation that results in the substitution of a proline for an alanine in a highly conserved...

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PMID: 7559435
DOI: 10.1074/jbc.270.39.22974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line.PMID 7559435Read ↗

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