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Article

Molecular mechanism of antifolate transport-deficiency in a methotrexate-resistant MOLT-3 human leukemia cell line.

Blood - 1 Apr 1997

Gong M, Yess J, Connolly T, Ivy S P, Ohnuma T, Cowan K H, Moscow J A

Abstract excerpt

Ohnuma et al reported a series of methotrexate-resistant MOLT-3 human T-cell acute lymphoblastic leukemia cell lines that showed decreasing methotrexate (MTX) uptake as the sublines acquired increasing MTX resistance (Cancer Res 45:1815, 1985). The alteration of MTX uptake kinetics in these cells...

Topics

Alleles
Antimetabolites, Antineoplastic
Biological Transport
Carrier Proteins
Codon
Drug Resistance, Neoplasm
Gene Expression Regulation, Leukemic
Humans
Leukemia-Lymphoma, Adult T-Cell
Membrane Proteins
Membrane Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methotrexate

Neoplasm Proteins

Terminator Regions, Genetic

Transfection

Tumor Cells, Cultured

Source

Identifiers

PMID: 9116294

Genes

RFC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9116294-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Molecular mechanism of antifolate transport-deficiency in a methotrexate-resistant MOLT-3 human leukemia cell line.PMID 9116294Read ↗

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