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Article

Functional role of arginine 373 in substrate translocation by the reduced folate carrier.

The Journal of biological chemistry - 1 Nov 2002

Sadlish Heather, Williams Frederick M R, Flintoff Wayne F

Abstract excerpt

The reduced folate carrier (RFC) plays a critical role in the cellular uptake of folates. However, little is known regarding the mechanism used to transport substrates or the tertiary structure of the protein. Through the analysis of a Chinese hamster ovary cell line deficient in folate uptake, we have identified a single residue in TM10 (Arg-373) of RFC that appears to play a critical role in the translocation...

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Identifiers

PMID: 12194981
DOI: 10.1074/jbc.M206459200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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