Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The relationship between the sibling recurrence-risk ratio and genotype relative risk.

American journal of human genetics - 1 Feb 2000

Rybicki B A, Elston R C

Abstract excerpt

The recurrence-risk ratio of disease in siblings, lambdaS, is a standard parameter used in genetic analysis to estimate the statistical power for detection of a disease locus. However, the relationship between the underlying risk conferred by a disease-susceptibility allele and lambdaS has not been well described. The former is generally quantified as a genotype relative risk, gamma, and measures the ratio of...

Topics

Alleles
Chromosome Mapping
Gene Frequency
Genes, Dominant
Genes, Recessive
Genetic Diseases, Inborn
Genetic Linkage
Genetic Predisposition to Disease
Genotype
Humans
Mathematics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Nuclear Family

Prevalence

Sarcoidosis

Source

Open in PubMed Open full text

Identifiers

PMID: 10677319
DOI: 10.1086/302778
PMCID: PMC1288112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10677319-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The relationship between the sibling recurrence-risk ratio and genotype relative risk.PMID 10677319Read ↗

Genotype-specific recurrence risks as indicators of the genetic architecture of complex diseases.Semantic proximity Read ↗

The contribution of genetic variants to disease depends on the ruler.Semantic proximity Read ↗

A perspective on epistasis: limits of models displaying no main effect.Semantic proximity Read ↗

Association mapping of complex diseases in linked regions: estimation of genetic effects and feasibility of testing rare variants.Semantic proximity Read ↗

Using discordant sib pairs to map loci for qualitative traits with high sibling recurrence risk.Semantic proximity Read ↗

Correcting for ascertainment bias of relative-risk estimates obtained using affected-sib-pair linkage data.Semantic proximity Read ↗

Power of sib-pair and sib-trio linkage analysis with assortative mating and multiple disease loci.Semantic proximity Read ↗

Testing for association between disease and linked marker loci: a log-linear-model analysis.Semantic proximity Read ↗

Linkage strategies for genetically complex traits. II. The power of affected relative pairs.Semantic proximity Read ↗

General epistatic models of the risk of complex diseases.Semantic proximity Read ↗

On the use of sibling recurrence risks to select environmental factors liable to interact with genetic risk factors.Semantic proximity Read ↗

Sibling recurrence risk in Dupuytren's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.