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Article

General epistatic models of the risk of complex diseases.

Genetics - 1 Dec 2010

Song Yun S, Wang Fulton, Slatkin Montgomery

Abstract excerpt

The range of possible gene interactions in a multilocus model of a complex inherited disease is studied by exploring genotype-specific risks subject to the constraint that the allele frequencies and marginal risks are known. We quantify the effect of gene interactions by defining the interaction ratio, CR=KR/KRI, where KR is the recurrence risk to relatives with relationship R for the true model and KRI is the...

Read the complete abstract on PubMed

Topics

Alleles
Epistasis, Genetic
Gene Frequency
Genetic Diseases, Inborn
Genetic Predisposition to Disease
Humans
Models, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Probability

Risk

Source

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Identifiers

PMID: 20855570
DOI: 10.1534/genetics.110.119008
PMCID: PMC2998324

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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