Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype-specific recurrence risks as indicators of the genetic architecture of complex diseases.

American journal of human genetics - 1 Jul 2008

Slatkin Montgomery

Abstract excerpt

A statistic is introduced that relates discoveries made in genome-wide association (GWA) studies to patterns of disease risks among relatives. The genotype-specific recurrence risk (GSR) is the genotype-specific risk to relatives of known relationship to affected probands. The GSRs can be used for three purposes. (1) They can provide an independent test of whether an allele identified in a GWA study is associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 10
Share to Genes
Share to Macular Degeneration

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mathematics

Share to Netherlands

Share to Recurrence

Share to Siblings

Source

Open in PubMed Open full text

Identifiers

PMID: 18597734
DOI: 10.1016/j.ajhg.2008.06.011
PMCID: PMC2443843

Genes

GSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype-specific recurrence risks as indicators of the genetic architecture of complex diseases.PMID 18597734Read ↗

The relationship between the sibling recurrence-risk ratio and genotype relative risk.Semantic proximity Read ↗

General epistatic models of the risk of complex diseases.Semantic proximity Read ↗

Study designs for identification of rare disease variants in complex diseases: the utility of family-based designs.Semantic proximity Read ↗

The contribution of genetic variants to disease depends on the ruler.Semantic proximity Read ↗

Personalized genetic counseling for Stargardt disease: Offspring risk estimates based on variant severity.Semantic proximity Read ↗

Exploring Genetic Interactions with Rare Variants Reveals Gene Networks Susceptible to Complex DiseasesSemantic proximity Read ↗

Beyond odds ratios--communicating disease risk based on genetic profiles.Semantic proximity Read ↗

Construction of gene clusters resembling genetic causal mechanisms for common complex disease with an application to young-onset hypertension.Semantic proximity Read ↗

Risk categorization for complex disorders according to genotype relative risk and precision in parameter estimates.Semantic proximity Read ↗

A perspective on epistasis: limits of models displaying no main effect.Semantic proximity Read ↗

Association mapping of complex diseases in linked regions: estimation of genetic effects and feasibility of testing rare variants.Semantic proximity Read ↗

Recurrence risk of autoimmune thyroid and endocrine diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.