Article
Using discordant sib pairs to map loci for qualitative traits with high sibling recurrence risk.
American journal of human genetics - 1 Dec 1996
Rogus J J, Krolewski A S
Abstract excerpt
A common approach for detecting genetic linkage using siblings is to collect affected sib pairs (ASPs) and to identify markers where allele sharing exceeds expectation. Alternatively, markers can be analyzed in discordant sib pairs (DSPs) for allele sharing below expectation. Relative to the ASP approach, according to Risch, the power of the DSP approach increases with sibling recurrence risk, the two approaches...
Topics
- Alleles
- Chromosome Mapping
- Diabetes Mellitus, Type 1
- Diabetic Nephropathies
- Disease Susceptibility
- Gene Frequency
- Genetic Linkage
- Humans
- Models, Genetic
- Nuclear Family
- Phenotype