Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Basic fibroblast growth factor confers a less malignant phenotype in MDA-MB-231 human breast cancer cells.

Cancer research - 1 Feb 2000

Korah R M, Sysounthone V, Golowa Y, Wieder R

Abstract excerpt

Basic fibroblast growth factor (FGF-2) expression is associated with a more differentiated phenotype, earlier stage of disease, and a better prognosis in breast cancer patients. To determine whether expression of FGF-2 can cause a less malignant phenotype, we engineered MDA-MB-231 cells, a highly dedifferentiated, invasive breast cancer cell line, to express different isoforms of FGF-2. Cells expressed either...

Topics

Animals
Breast Neoplasms
Cell Division
Female
Humans
Matrix Metalloproteinases
Mice
Mice, Inbred BALB C
Molecular Weight
Neoplasm Invasiveness
Phenotype
Receptors, Fibroblast Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Source

Identifiers

PMID: 10676661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Basic fibroblast growth factor confers a less malignant phenotype in MDA-MB-231 human breast cancer cells.PMID 10676661Read ↗

Intracellular FGF-2 promotes differentiation in T-47D breast cancer cells.Semantic proximity Read ↗

Less is more: low expression of MT1-MMP is optimal to promote migration and tumourigenesis of breast cancer cells.Semantic proximity Read ↗

TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells.Semantic proximity Read ↗

Altered Metastatic Behavior of Human Breast Cancer Cells after Experimental Manipulation of Matrix Metalloproteinase 8 Gene ExpressionSemantic proximity Read ↗

Differential modulation of cell phenotype by different molecular weight forms of basic fibroblast growth factor: possible intracellular signaling by the high molecular weight forms.Semantic proximity Read ↗

The invasive phenotype in HMT-3522 cells requires increased EGF receptor signaling through both PI 3-kinase and ERK 1,2 pathways.Semantic proximity Read ↗

p38MAPK induces cell surface alpha4 integrin downregulation to facilitate erbB-2-mediated invasion.Semantic proximity Read ↗

Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells.Semantic proximity Read ↗

A highly invasive subpopulation of MDA-MB-231 breast cancer cells shows accelerated growth, differential chemoresistance, features of apocrine tumors and reduced tumorigenicity in vivo.Semantic proximity Read ↗

EphB6 receptor significantly alters invasiveness and other phenotypic characteristics of human breast carcinoma cells.Semantic proximity Read ↗

Invading basement membrane matrix is sufficient for MDA-MB-231 breast cancer cells to develop a stable in vivo metastatic phenotype.Semantic proximity Read ↗

The malignant phenotype of breast cancer cells is reduced by COX-2 silencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.