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Article

The malignant phenotype of breast cancer cells is reduced by COX-2 silencing.

Neoplasia (New York, N.Y.) - 1 Nov 2008

Stasinopoulos Ioannis, Mori Noriko, Bhujwalla Zaver M

Abstract excerpt

The cyclooxygenase (COX) pathway is currently targeted for therapeutic intervention in different cancers. We have previously shown that silencing of COX-2 in the poorly differentiated metastatic breast cell line MDA-MB-231 by RNA interference markedly delayed tumor onset and inhibited metastasis. To understand the functional effects of COX-2 silencing underlying the inhibition of tumor growth and metastasis...

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Identifiers

PMID: 18953425
DOI: 10.1593/neo.08568
PMCID: PMC2570592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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