Article
Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1995
Zutter M M, Santoro S A, Staatz W D, Tsung Y L
Abstract excerpt
To assess the role of altered alpha 2 beta 1 integrin expression in breast cancer, we expressed the alpha 2 beta 1 integrin de novo in a poorly differentiated mammary carcinoma that expressed no detectable alpha 2-integrin subunit. Expression of the alpha 2 beta 1 integrin resulted in a dramatic phenotypic alteration from a fibroblastoid, spindle-shaped, non-contact-inhibited, motile, and invasive cell to an...
Topics
- Animals
- Cell Adhesion
- Cell Differentiation
- Cell Division
- Cell Movement
- Female
- Gene Expression
- Integrins
- Mammary Neoplasms, Experimental
- Mice
- Neoplasm Invasiveness