TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells.

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Article

TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells.

International journal of oncology - 1 Nov 2004

Kim Eun-Sook, Kim Mi-Sung, Moon Aree

Abstract excerpt

Transforming growth factor (TGF)-beta has been reported to exert growth inhibitory activity in normal epithelial cells whereas it induces cell proliferation and invasive phenotypes in advanced carcinomas. Our previous study showed that MCF10A, a spontaneously immortalized "normal" breast epithelial cell line, is resistant to TGF-beta-induced growth inhibition, suggesting that conversion of TGF-beta growth...

Topics

Breast Neoplasms
Cell Movement
Cell Transformation, Neoplastic
Disease Progression
Epithelial Cells
Female
Humans
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Phenotype
Signal Transduction
Transforming Growth Factor beta
Up-Regulation
p38 Mitogen-Activated Protein Kinases

Source

Open in PubMed

Identifiers

PMID: 15492828

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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