Invading basement membrane matrix is sufficient for MDA-MB-231 breast cancer cells to develop a stable in vivo metastatic phenotype.

doi:10.1371/journal.pone.0023334

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Article

Invading basement membrane matrix is sufficient for MDA-MB-231 breast cancer cells to develop a stable in vivo metastatic phenotype.

PloS one - 1 Jan 2011

Abdelkarim Mohamed, Vintonenko Nadejda, Starzec Anna, Robles Aniela, Aubert Julie, Martin Marie-Laure, Mourah Samia, Podgorniak Marie-Pierre, Rodrigues-Ferreira Sylvie, Nahmias Clara, Couraud Pierre-Olivier, Doliger Christelle, Sainte-Catherine Odile, Peyri Nicole, Chen Lei, Mariau Jérémie, Etienne Monique, Perret Gerard-Yves, Crepin Michel, Poyet Jean-Luc, Khatib Abdel-Majid, Di Benedetto Mélanie

Abstract excerpt

INTRODUCTION: The poor efficacy of various anti-cancer treatments against metastatic cells has focused attention on the role of tumor microenvironment in cancer progression. To understand the contribution of the extracellular matrix (ECM) environment to this phenomenon, we isolated ECM surrogate invading cell populations from MDA-MB-231 breast cancer cells and studied their genotype and malignant phenotype....

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PMID: 21858074
DOI: 10.1371/journal.pone.0023334
PMCID: PMC3156115

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